BDBM50029668 AZD-9291::Osimertinib::US10085983, Compound AZD-9291::US10227342, Example 24::US11111233, Example AZD9291::US20230322822, Compound AZD9291::US9890168, Compound AZD-9291::WO2022090481, Example osimertinib

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12

InChI Key InChIKey=DUYJMQONPNNFPI-UHFFFAOYSA-N

Data  7 KI  206 IC50  21 EC50

PDB links: 10 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50029668   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of wildtype EGFR (unknown origin) using biotin as substrate in presence of ATP by mobility shift assay based ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using biotin as substrate in presence of ATP by mobility shift assay based ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using substrate-biotin by ELISA-based mobility shift assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using substrate-biotin by ELISA-based mobility shift assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using substrate-biotin by ELISA-based mobility shift assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using substrate-biotin by ELISA-based mobility shift assayMore data for this Ligand-Target Pair