BDBM50031299 6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamine::6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamine(lamotrigine)::6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine::BW-430C::CHEMBL741::LAMOTRIGINE::Lamictal::Lamictal cd

SMILES Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N

Data  2 KI  26 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50031299   

LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human Nav1.2 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed