BDBM50032693 CHEBI:66901::Ivacaftor::Kalydeco::VX-770

SMILES CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C

InChI Key InChIKey=PURKAOJPTOLRMP-UHFFFAOYSA-N

Data  8 IC50  11 EC50

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50032693   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  236nMAssay Description:Corrector activity at human bronchial epithelium CFTR F508del and G551D mutant assessed as increase in channel gatingMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  34nMAssay Description:Potentiation of wild type CFTR (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskolin and amilo...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  236nMAssay Description:Potentiation of human CFTR F508del mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  22nMAssay Description:Potentiation of human CFTR F508del/G551D mutant in human bronchial epithelial cells by Ussing chambers recording techniqueMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assayMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  12nMAssay Description:Potentiator activity at CFTR F508del mutant (unknown origin) expressed in CFBE41o cells assessed as increase in forskolin induced transepithelial sho...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  49nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presenc...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  70nMAssay Description:Potentiation of wild-type CFTR (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence of ...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  131nMAssay Description:Potentiation of CFTR G551D mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence ...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  68nMAssay Description:Potentiation of CFTR F508 deletion mutant (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskoli...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assayMore data for this Ligand-Target Pair