BDBM50032693 CHEBI:66901::Ivacaftor::Kalydeco::VX-770
SMILES CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C
InChI Key InChIKey=PURKAOJPTOLRMP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50032693
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma
Curated by ChEMBL
Jl3Pharma
Curated by ChEMBL
Affinity DataEC50: 236nMAssay Description:Corrector activity at human bronchial epithelium CFTR F508del and G551D mutant assessed as increase in channel gatingMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma
Curated by ChEMBL
Jl3Pharma
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assayMore data for this Ligand-Target Pair