BDBM50032693 CHEBI:66901::Ivacaftor::Kalydeco::VX-770

SMILES CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C

InChI Key InChIKey=PURKAOJPTOLRMP-UHFFFAOYSA-N

Data  8 IC50  11 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50032693   

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  236nMAssay Description:Corrector activity at human bronchial epithelium CFTR F508del and G551D mutant assessed as increase in channel gatingMore data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Jl3Pharma

Curated by ChEMBL
LigandPNGBDBM50032693(CHEBI:66901 | Ivacaftor | Kalydeco | VX-770)
Affinity DataEC50:  3nMAssay Description:Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assayMore data for this Ligand-Target Pair