BDBM50032888 CHEMBL3342778::US9290459, 6.3::US9670166, 6.3

SMILES FC(F)(F)c1cccc(c1)N1C2=C(C(N(CC(=O)N3CCC3)C1=O)c1ccc(cc1)C#N)C(=O)CC2

InChI Key InChIKey=MAAIYZJSIBUOTJ-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50032888   

TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50032888(CHEMBL3342778 | US9290459, 6.3 | US9670166, 6.3)
Affinity DataEC50:  4nMpH: 7.5Assay Description:Various concentrations of the neutrophil elastase inhibitor are incubated with plasma. Subsequently, the enzyme activity is measured using the fluoro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50032888(CHEMBL3342778 | US9290459, 6.3 | US9670166, 6.3)
Affinity DataIC50:  3.70nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50032888(CHEMBL3342778 | US9290459, 6.3 | US9670166, 6.3)
Affinity DataIC50:  3.70nMpH: 7.5 T: 2°CAssay Description:Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50032888(CHEMBL3342778 | US9290459, 6.3 | US9670166, 6.3)
Affinity DataEC50:  4nMAssay Description:Inhibition of neutrophil elastase in human plasma using MeOSuc-Ala-Ala-Pro-Val-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50032888(CHEMBL3342778 | US9290459, 6.3 | US9670166, 6.3)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human neutrophil elastase using MeOSuc-Ala-Ala-Pro-Val-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed