BDBM50033447 2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-tolyl-piperazin-1-yl)-ethanone::CHEMBL120055::CHEMBL321818

SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1

InChI Key InChIKey=DWSOZYFSYVOVOC-UHFFFAOYSA-N

Data  9 KI  9 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50033447   

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  0.800nMAssay Description:Affinity for 5-hydroxytryptamine 1B receptor subtypeMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity for cloned human 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor beta was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  2nMAssay Description:Affinity for 5-hydroxytryptamine 1D receptor subtypeMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to recombinant human 5-hydroxytryptamine 1D receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  2.10nMAssay Description:Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ...More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity towards cloned human 5-hydroxy tryptamine 1A (5-HT1A) receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  8nMAssay Description:Binding affinity for cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataKi:  8nMAssay Description:Affinity for 5-hydroxytryptamine 1A receptor subtypeMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataEC50:  110nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A/2B/2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cells; va...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptor alpha was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataEC50:  2.10nMAssay Description:The compound was evaluated for intrinsic activity against human cloned 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2b(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its affinity towards Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its affinity towards 5-hydroxytryptamine 1C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataEC50:  0.600nMAssay Description:Compound was tested for its ability inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-hydroxytryptamine 1D receptor beta ...More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its affinity towards 5-hydroxy tryptamine 4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its affinity towards dopaminergic (D2) receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its affinity towards histaminergic (H 1) receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50033447(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was tested for its affinity towards muscarinic (M) receptorMore data for this Ligand-Target Pair
In DepthDetails Article