BDBM50048512 CHEMBL299639::[(S)-3-((S)-2-Mercapto-3-phenyl-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid::[3-((S)-2-Mercapto-3-(S)-phenyl-propionylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetic acid

SMILES OC(=O)CN1c2ccccc2CC[C@H](NC(=O)[C@@H](S)Cc2ccccc2)C1=O

InChI Key InChIKey=TYXFDFMUHPWCDX-WMZOPIPTSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50048512   

TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme isolated from rabbit lung extract.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of purified rat kidney Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  12nMAssay Description:Tested in vitro for inhibition of Angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  6.10nMAssay Description:Tested in vitro for inhibition of neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of neutral endopeptidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  12nMAssay Description:Inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory activity against angiotensin converting enzyme (ACE) in rat was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  12nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50048512(CHEMBL299639 | [(S)-3-((S)-2-Mercapto-3-phenyl-pro...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Neutral Endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article