BDBM50049478 1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-yl}-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide [3a(MK-0677)]::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide(MK-0677)::CHEMBL13817::MK 0677::MK-0677::MK-677

SMILES CC(C)(C(=O)N[C@H](COCc1ccccc1)C(=O)N2CCC3(CC2)CN(c4c3cccc4)S(=O)(=O)C)N

InChI Key InChIKey=UMUPQWIGCOZEOY-UHFFFAOYSA-N

Data  8 KI  8 IC50  1 Kd  5 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50049478   

TargetGrowth hormone secretagogue receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  0.240nMAssay Description:Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGrowth hormone secretagogue receptor type 1 [E24Q](Human)
Université Montpellier 1

LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  8.90nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  9.90nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDimer of Growth hormone secretagogue receptor type 1(Human)
Université Montpellier 1

LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  10.2nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGrowth hormone secretagogue receptor type 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  65.8nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDimer of Growth hormone secretagogue receptor type 1(Human)
Université Montpellier 1

LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  68.4nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGrowth hormone secretagogue receptor type 1 [E24Q](Human)
Université Montpellier 1

LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  68.9nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50049478BDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataKi:  90.6nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)