BDBM50056904 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid::CHEMBL171637::NSC-685589::Physodic acid, 5::cid_65751::physodic acid

SMILES CCCCCC(=O)Cc1cc(O)cc2Oc3c(OC(=O)c12)cc(O)c(C(O)=O)c3CCCCC

InChI Key InChIKey=KVTYWHGIZSCFLG-UHFFFAOYSA-N

Data  10 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50056904   

TargetKinesin-like protein KIF20B(Human)
University College London

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetKinesin-like protein KIF20B(Human)
University College London

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetKinesin-like protein KIF20B(Human)
University College London

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in Escherichia coli B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetKinesin-like protein KIF20B(Human)
University College London

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
University College London

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of basal ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 3.09E+4nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1&2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 3.25E+4nMAssay Description:Inhibitory concentration of compound against disintegration (reversal of strand transfer)of HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 3.85E+4nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1&2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetCentromere-associated protein E(Human)
University College London

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 9.14E+4nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Human)
Yale University School of Medicine

LigandChemical structure of BindingDB Monomer ID 50056904BDBM50056904(cid_65751 | 3,8-Dihydroxy-11-oxo-1-(2-oxo-heptyl)-...)
Affinity DataIC50: 2.50E+5nMAssay Description:The labeled fragment can be distinguished from full-length MKK by a change in fluorescence polarization. MKK6 was used as a substrate because it cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2012
Entry Details Article
PubMed