BDBM50056944 4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-ethyl}-benzamide::CHEMBL368061

SMILES Fc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12

InChI Key InChIKey=POZFPYZCVYTCQZ-UHFFFAOYSA-N

Data  17 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50056944   

Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  58nMAssay Description:Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  58nMAssay Description:Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  130nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  190nMAssay Description:Inhibition of [3H]DTG binding to sigma receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  740nMAssay Description:Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  740nMAssay Description:Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.61E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  2.61E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3B(Mus musculus)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  3.47E+3nMAssay Description:Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor in NG cells 108-15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  4.05E+3nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 1C receptor of pig choroid PlexusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  4.05E+3nMAssay Description:Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 1C receptor of pig choroid PlexusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Sus scrofa)
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataKi:  9.77E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor using [3H]5-HT in pig striatum + frontalCortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Cooperation Pharmaceutique Fran�Aise

Curated by ChEMBL
LigandPNGBDBM50056944(4-Fluoro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed