BDBM50062599 3,5-Dimethyl-adamantan-1-ylamine::CHEMBL807::EN300-123026::MEMANTINE::Namenda::US10214478, Compound memantine
SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2
InChI Key InChIKey=BUGYDGFZZOZRHP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50062599
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assess...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University Of Barcelona
Curated by ChEMBL
University Of Barcelona
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assesse...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of equine serum BChE by modified Ellman's methodMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Universitat De Barcelona
Curated by ChEMBL
Universitat De Barcelona
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV h...More data for this Ligand-Target Pair
Affinity DataIC50: 2.72E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
University Of Bologna
Curated by ChEMBL
University Of Bologna
Curated by ChEMBL
Affinity DataIC50: 9.52E+3nMAssay Description:Inhibition of NMDA NR1/NR2B receptor (unknown origin) expressed in xenopus oocytes assessed as inhibition of NMDA and glycine-induced current respons...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
Hiroshima University
Curated by ChEMBL
Hiroshima University
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at rat brain GluN1/GluN2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced channe...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Universitat De Barcelona
Curated by ChEMBL
Universitat De Barcelona
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:Antagonist activity at rat brain GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced channe...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Affinity DataIC50: 4.36E+3nMpH: 7.6Assay Description:Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University Of Barcelona
Curated by ChEMBL
University Of Barcelona
Curated by ChEMBL
Affinity DataIC50: 1.02E+3nMAssay Description:Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Affinity DataIC50: 911nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Antagonist activity at GluN1a/GluN2A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage clamp methodMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human GluN1-1a/NR2A receptor expressed in transgenic mouse fibroblast cells assessed as inhibition of L-glutamate-induced excitotoxicit...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
University Of Jena
Curated by ChEMBL
University Of Jena
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human GluN1-1a/NR2B receptor expressed in transgenic mouse fibroblast cells assessed as inhibition of L-glutamate-induced excitotoxicit...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of electric eel AChE by modified Ellman's methodMore data for this Ligand-Target Pair