BDBM50068775 2H-Isoquinolin-1-one::CHEMBL339695::isoquinolin-1(2H)-one

SMILES O=c1[nH]ccc2ccccc12

InChI Key InChIKey=VDBNYAPERZTOOF-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50068775   

TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50068775(2H-Isoquinolin-1-one | CHEMBL339695 | isoquinolin-...)
Affinity DataKi:  1.90E+7nMAssay Description:Inhibition of human soluble tissue factor/factor VIIa expressed in Origami B (DE3) using D-Ile-Pro-Arg-pNA as substrate after 30 mins by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50068775(2H-Isoquinolin-1-one | CHEMBL339695 | isoquinolin-...)
Affinity DataIC50:  7.00E+3nMAssay Description:The compound was tested for poly(ADP-ribose)polymerase (PARP) inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50068775(2H-Isoquinolin-1-one | CHEMBL339695 | isoquinolin-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Mus musculus)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068775(2H-Isoquinolin-1-one | CHEMBL339695 | isoquinolin-...)
Affinity DataIC50:  1.58E+4nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeregrin(Homo sapiens (Human))
University Of Z£Rich

Curated by ChEMBL
LigandPNGBDBM50068775(2H-Isoquinolin-1-one | CHEMBL339695 | isoquinolin-...)
Affinity DataKd: >2.00E+5nMAssay Description:Binding affinity to recombinant GST-tagged human BRPF1 expressed in Escherichia coli BL21 (DE3) after 1 hr by qPCR-based BromoScan assayMore data for this Ligand-Target Pair