BDBM50070921 3-[(3R,4R)-6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy-chroman-3-ylmethyl]-benzoic acid::3-[6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy-chroman-3-ylmethyl]-benzoic acid::CHEMBL442150

SMILES O[C@@H]1[C@H](Cc2cccc(c2)C(O)=O)COc2ccc(OCc3nc4cc(F)ccc4s3)cc12

InChI Key InChIKey=RYSLZFOZDSIPHK-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50070921   

LigandPNGBDBM50070921(3-[6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of 5-Lipoxygenase (5-LO) in rat basophilic leukemic cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetCysteinyl leukotriene receptor 1(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50070921(3-[6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy...)
Affinity DataKi:  14nMAssay Description:Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50070921(3-[6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy...)
Affinity DataKi:  14nMAssay Description:Ability to antagonize LTD4 receptors isolated from guinea pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50070921(3-[6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4-hydroxy...)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of [3H]LTD4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article