BDBM50075053 CHEMBL3414618

SMILES CC(C)n1ncc2c(cc(nc12)-c1ccc2OCCOc2c1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=PHHBPZAKJMTXPV-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50075053   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075053(CHEMBL3414618)
Affinity DataKi:  310nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075053(CHEMBL3414618)
Affinity DataIC50:  500nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075053(CHEMBL3414618)
Affinity DataIC50:  620nMAssay Description:Inhibition of human EZH2 using SAM and histone H3 (16 to 30) as substrate preincubated for 30 mins followed by substrate addition measured after 90 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075053(CHEMBL3414618)
Affinity DataIC50:  500nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed