BDBM50076662 CHEMBL174684::methyl 1-methyl-3-[1-(4-methoxyphenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]prop-2-ynyl(hydroxy)carbamate

SMILES COC(=O)N(O)C(C)C#Cc1cc(-c2ccc(C)cc2)n(n1)-c1ccc(OC)cc1

InChI Key InChIKey=PYLHIEWFFQYPSV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076662   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076662(CHEMBL174684 | methyl 1-methyl-3-[1-(4-methoxyphen...)
Affinity DataIC50:  530nMAssay Description:Inhibitory activity against Cyclooxygenase using sheep seminal vesicle (SSV) enzyme (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076662(CHEMBL174684 | methyl 1-methyl-3-[1-(4-methoxyphen...)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076662(CHEMBL174684 | methyl 1-methyl-3-[1-(4-methoxyphen...)
Affinity DataIC50:  490nMAssay Description:Inhibitory activity against cyclooxygenase (COX) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076662(CHEMBL174684 | methyl 1-methyl-3-[1-(4-methoxyphen...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against Cyclooxygenase (COX) using broken rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50076662(CHEMBL174684 | methyl 1-methyl-3-[1-(4-methoxyphen...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed