BDBM50085045 5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy)phenyl)methyl)thiazolidine-2,4-dione::5-(4-((6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione::5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzy l]-thiazolidine-2,4-dione (troglitazone)::5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione::5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dione(troglitazone)::5-[4-(6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-ylmethoxy)-benzyl]-thiazolidine-2,4-dioneTroglitazone::CHEMBL408::CI-991::CS-045::GR92132X::PRELAY::REZULIN::TROGLITAZONE
SMILES Cc1c(C)c2OC(C)(COc3ccc(Cc4sc(=O)[nH]c4O)cc3)CCc2c(C)c1O
InChI Key InChIKey=BJWJSFCBOIUATF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 52 hits for monomerid = 50085045
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Activation of PPARgamma transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to controlMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 730nMAssay Description:Transactivation of GAL4-fused PPARgamma LBD expressed in HepG2 cells after 20 hrs by luminescence assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 440nMAssay Description:Agonist activity at human recombinant PPARgamma expressed in CHO cells cotransfected with pGL3-PPRE3-TK-luc reporter assessed as beta-galactosidase a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of human recombinant MAO-B after 15 minsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Transactivation of human PPARgamma expressed in african green monkey CV1 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Mouse)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of 15-LOX-mediated lipid oxidation in 10% C57BL/6J mouse plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Binding affinity to GST-tagged human PPARgamma by TR-FRET analysisMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 215nMAssay Description:Agonist activity at PPARgamma (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin) by nuclear receptor cofactor assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+5nMAssay Description:Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as disruption of FOXM1-DNA complex prein...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human BSEP expressed in HEK293 cell membrane vesicles assessed as reduction in 3H-TCA uptake incubated for 5 mins by radiodetection met...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 1.38E+3nMAssay Description:Agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide fluorescein-TRAP220/DRIP by TR-FRET ass...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 1.50E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin) assessed as increase in fluorescein labeled TRAP220/DRIP-2 coactivator peptide requirement by Lanthasc...More data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of recombinant human MAO-BMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Agonist activity at human PPAR-gamma expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Kyoto Pharmaceutical University
Curated by ChEMBL
Kyoto Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at PPARgamma in mouse 3T3L1 cellsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 537nMAssay Description:Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection as...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Kyoto Pharmaceutical University
Curated by ChEMBL
Kyoto Pharmaceutical University
Curated by ChEMBL
Affinity DataEC50: 780nMAssay Description:Agonist activity for murine PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 550nMAssay Description:Agonist activity for Human PPAR gamma receptor in transcriptional activation assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Binding affinity at human peroxidase proliferator activated receptor gamma (hPPARgamma)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 2.24E+3nMAssay Description:Binding affinity at human PPAR gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 980nMAssay Description:In vitro transactivation using receptor transactivation assay against hPPAR gammaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 2.60E+3nMAssay Description:Agonist activity at PPARgamma receptor by cofactor assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of mouse Ido1 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotom...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 440nMAssay Description:Agonist activity at human PPARgamma expressed in CHO cells co-transfected with pGL3-PPRE3-TK-luc assessed as transactivation after 24 hrs by firefly ...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of fluormone binding to human PPARgamma LBD after 2 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotom...More data for this Ligand-Target Pair
Affinity DataIC50: 6.64E+4nMAssay Description:TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP)More data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake (Taurocholate: 1 uM) in liver canalicular membrane vesicle from female ratMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 2.24E+3nMAssay Description:Displacement of tritium labeled ligand from human PPARgamma by SPA assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataEC50: 720nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as disruption of FOXM1-DNA complex prein...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to controlMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataKi: 302nMAssay Description:In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataKi: 380nMAssay Description:Displacement of fluormone Pan-PPAR Green from human GST-tagged PPARgamma-LBD by TR-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Binding affinity to human recombinant PPARgamma by Cheng-Prusoff equation based competitive binding TR-FRET assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataKi: 3.80E+3nMAssay Description:inhibition of [125I]SB 236636 binding to human PPAR gamma receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.80E+3nMAssay Description:Uncompetitive inhibition of rat MAOA expressed in Pichia pastorisMore data for this Ligand-Target Pair
Affinity DataKi: 9.50E+3nMAssay Description:Uncompetitive inhibition of human MAOB expressed in Pichia pastorisMore data for this Ligand-Target Pair
Affinity DataKi: 1.05E+4nMAssay Description:Uncompetitive inhibition of human MAOA expressed in Pichia pastorisMore data for this Ligand-Target Pair