BDBM50087703 CHEMBL427807::Urocortin-human(DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2)::analogue of human corticotropin-releasing factor (hCRF)

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O

InChI Key InChIKey=BIIOOWPFSOAZSO-PSXOHVDKSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50087703   

TargetCorticotropin-releasing factor receptor 2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50087703(CHEMBL427807 | Urocortin-human(DNPSLSIDLTFHLLRTLLE...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity of the receptor h-CRF2-alpha with peptidic agonistsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50087703(CHEMBL427807 | Urocortin-human(DNPSLSIDLTFHLLRTLLE...)
Affinity DataKi:  3.76nMAssay Description:Binding affinity of the receptor corticotropin releasing factor receptor with peptidic agonistsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50087703(CHEMBL427807 | Urocortin-human(DNPSLSIDLTFHLLRTLLE...)
Affinity DataEC50:  0.220nMAssay Description:Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 2(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50087703(CHEMBL427807 | Urocortin-human(DNPSLSIDLTFHLLRTLLE...)
Affinity DataEC50:  0.320nMAssay Description:Activity of peptidic agonists on h-CRF2-alpha receptor using agonist-stimulated adenylate cyclase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed