BDBM50088426 (1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol::3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentane-1,2-diol::CHEMBL49935

SMILES Nc1ncnc2n(cnc12)[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O

InChI Key InChIKey=UGRNVLGKAGREKS-UHFFFAOYSA-N

Data  7 KI  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50088426   

TargetAdenosylhomocysteinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50088426(3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentan...)
Affinity DataIC50: 303nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosylhomocysteinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50088426(3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentan...)
Affinity DataIC50: 4.85E+3nMAssay Description:Inhibition of human SAHHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosylhomocysteinase(Plasmodium falciparum (isolate 3D7))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50088426(3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentan...)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of Plasmodium falciparum SAHHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosylhomocysteinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50088426(3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentan...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of human placental SAH hydrolase expressed in Escherichia coli JM109 using SAH as substrate preincubated for 10 mins followed by SAH addit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed