BDBM50089882 CHEMBL3581047

SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1

InChI Key InChIKey=BFGQGBCFWCMBDY-PSXMRANNSA-N

Data  3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50089882   

TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50089882(CHEMBL3581047)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C41H36N6O3/c1-50-32-21-18-29(19-22-32)27-47-37(23-20-28-11-4-2-5-12-28)45-46-40(47)36(25-31-26-43-35-17-9-8-15-33(31)35)44-41(49)38-34(16-10-24-42-38)39(48)30-13-6-3-7-14-30/h2-19,21-22,24,26,36,43H,20,23,25,27H2,1H3,(H,44,49)/t36-/m1/s1
Affinity DataIC50: 240nMAssay Description:Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50089882(CHEMBL3581047)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C41H36N6O3/c1-50-32-21-18-29(19-22-32)27-47-37(23-20-28-11-4-2-5-12-28)45-46-40(47)36(25-31-26-43-35-17-9-8-15-33(31)35)44-41(49)38-34(16-10-24-42-38)39(48)30-13-6-3-7-14-30/h2-19,21-22,24,26,36,43H,20,23,25,27H2,1H3,(H,44,49)/t36-/m1/s1
Affinity DataIC50: 230nMAssay Description:Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50089882(CHEMBL3581047)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C41H36N6O3/c1-50-32-21-18-29(19-22-32)27-47-37(23-20-28-11-4-2-5-12-28)45-46-40(47)36(25-31-26-43-35-17-9-8-15-33(31)35)44-41(49)38-34(16-10-24-42-38)39(48)30-13-6-3-7-14-30/h2-19,21-22,24,26,36,43H,20,23,25,27H2,1H3,(H,44,49)/t36-/m1/s1
Affinity DataIC50: 313nMAssay Description:Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CR...More data for this Ligand-Target Pair