BDBM50109454 1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea::1-(4-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea::CHEMBL167753

SMILES Cn1cc2c(n1)nc(NC(=O)Nc1ccc(Cl)cc1)n1nc(nc21)-c1ccco1

InChI Key InChIKey=YNNNCAAPQRZSHQ-UHFFFAOYSA-N

Data  9 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50109454   

TargetAdenosine receptor A3(Homo sapiens (Human))TBA
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity to human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A3(Homo sapiens (Human))TBA
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]-MRE3008-F20 from human Adenosine A3 receptor expressed in HEK cells; range 0.23-0.36More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))TBA
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))TBA
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity for human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Università degli Studi di Ferrara

Curated by ChEMBL
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK-293 cells; range 115-143More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Università degli Studi di Ferrara

Curated by ChEMBL
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-SCH-58,261 from human Adenosine A2A receptor expressed in HEK-293 cells; range 162-200More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Università degli Studi di Ferrara

Curated by ChEMBL
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))TBA
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  288nMAssay Description:Displacement of [3H]MRE3008-F20 from human adenosine A3 receptor expressed in CHO cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Università degli Studi di Ferrara

Curated by ChEMBL
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataKi:  430nMAssay Description:Displacement of [3H]-DPCPX from human Adenosine A1 receptor expressed in CHO cells; range 351-526More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))TBA
LigandPNGBDBM50109454(1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-py...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of IB-MECA agonist-mediated cAMP production in membranes of CHO cells expressing human Adenosine A3 receptor; range 1.2-4.9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed