BDBM50113851 (+/-)-Tranylcypromine::2-PCPA::2-Phenyl-cyclopropylamine::2-phenylcyclopropanamine::CHEMBL313833::TRANYLCYPROMINE::Tranylcypromine,(+)::Tranylcypromine,(-)::US8609708, 6 Tranyl- cypromine::US8609708, 6 Tranylcypromine

SMILES NC1CC1c1ccccc1

InChI Key InChIKey=AELCINSCMGFISI-UHFFFAOYSA-N

Data  12 KI  33 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50113851   

TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
John Hopkins University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of MAO-B (unknown origin) by MAo-Glo kit analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.42E+5nMAssay Description:Irreversible inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.48E+4nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  7.87E+3nMAssay Description:Inhibition of human MAOA using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid substrate incubated for 60 mins by luciferin de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
John Hopkins University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human MAOB using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid substrate incubated for 60 mins by luciferin de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of N-terminal hexahistidine-tagged human LSD1 (1 to 852 amino acid residues) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
John Hopkins University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human MAO-B using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human MAO-A using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 2(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.30E+6nMAssay Description:Inhibition of recombinant human LSD2 using H3K4 peptide as substrate assessed as decrease in H3K4 demethylation after 1 hr by mass spectroscopic anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of human LSD1 using H3K4 peptide as substrate by peroxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
John Hopkins University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of MAOBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.93E+4nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
John Hopkins University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.95E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  4.72E+3nMAssay Description:Inhibition of MAOA (unknown origin) using beetle luciferin as substrate by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
John Hopkins University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected insect cells by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected insect cells by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 2(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human full length LSD2 using biotin-labeled H3K4me2 (1 to 24 residues) as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of MAO-A (unknown origin) by MAo-Glo kit analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.42E+5nMAssay Description:Inhibition of human recombinant LSD1 after 30 mins to 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastoris incubated for 20 mins by bioluminescent-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli assessed as reduction in H2O2 release using synthetic mono-methylated H3-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
John Hopkins University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  1.05E+3nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris incubated for 15 mins by bioluminescent-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin) using 7-ethoxy-3-cyanocoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Telormedix

US Patent
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  6.90E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  5.00E+3nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

US Patent
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  970nMAssay Description:The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

US Patent
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  80nMAssay Description:The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2A6(Homo sapiens (Human))
Human Biomolecular Research Institute

US Patent
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  970nMAssay Description:The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  1.84E+5nMAssay Description:The kinetic inhibition parameters of LSD1 demethylase inhibition were obtained using the peroxidase-coupled reaction method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Southampton

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant LSD1 assessed as effect on H2O2 production incubated for 30 mins using methylated peptide substrate, Amplex red reage...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed