BDBM50116521 CHEMBL3609819
SMILES [H][C@]12C[C@](CCN(C)CCCc3nc4cccc(OC)c4[nH]3)(OC(=O)C(C)C)[C@]([H])(CCC1)c1ccccc21
InChI Key InChIKey=OZBPEBNJOSXIBE-SKYBXZRDSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50116521
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Actelion Pharmaceuticals
Curated by ChEMBL
Actelion Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <400nMAssay Description:Inhibition of human ERG expressed in HEK cells by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as reduction in diclofenac 4'-hydroxylation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextromethorphan-O demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Actelion Pharmaceuticals
Curated by ChEMBL
Actelion Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in testosterone 6beta-hydroxylation by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Actelion Pharmaceuticals
Curated by ChEMBL
Actelion Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 387nMAssay Description:Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes assessed as reduction in testosterone 6beta-hydroxylation incubated for 60 mins in pres...More data for this Ligand-Target Pair