BDBM50130293 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one::ARIPIPRAZOLE::CHEMBL1112::US10174011, aripiprazole::US10752588, Compound Aripiprazole::US11498896, Compound Aripiprazole::US9018213, aripprazole::US9156822, Aripiprazole
SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
InChI Key InChIKey=CEUORZQYGODEFX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50130293
Affinity DataEC50: 12nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing GFP2-beta-arrestin2 assessed as beta-arrestin2 recr...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Medical University Of Warsaw
Curated by ChEMBL
Medical University Of Warsaw
Curated by ChEMBL
Affinity DataEC50: 450nMAssay Description:Cell Culture: Chinese Hamster Ovary (CHO) cells stably expressing the hD2L dopamine receptor (Urban et al., Neuropsychopharmacology 32:67 (2007)) wer...More data for this Ligand-Target Pair
3D Structure (crystal)TargetD(3) dopamine receptor(Homo sapiens (Human))
Case Western Reserve University
Curated by PDSP Ki Database
Case Western Reserve University
Curated by PDSP Ki Database
Affinity DataEC50: 20nMAssay Description:Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding a...More data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells co-expressing Galphai2 after 30 mins by [35S]GTPgammaS bin...More data for this Ligand-Target Pair
Affinity DataEC50: 158nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...More data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Medical University Of Warsaw
Curated by ChEMBL
Medical University Of Warsaw
Curated by ChEMBL
Affinity DataEC50: 285nMAssay Description:Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human D2L receptor expressed in HEK293T cells coexpressing Gi subunit assessed as inhibition of isoproterenol-stimulated cAMP pro...More data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Medical University Of Warsaw
Curated by ChEMBL
Medical University Of Warsaw
Curated by ChEMBL
Affinity DataEC50: 1.88E+3nMAssay Description:The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ...More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Case Western Reserve University
Curated by PDSP Ki Database
Case Western Reserve University
Curated by PDSP Ki Database
Affinity DataEC50: 19nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Case Western Reserve University
Curated by PDSP Ki Database
Case Western Reserve University
Curated by PDSP Ki Database
Affinity DataEC50: 20nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
Affinity DataEC50: 4.80nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
Affinity DataEC50: 158nMAssay Description:Agonist activity at human Dopamine D2S receptor expressed in HEK293T cell membranes coexpressing Galphai2 incubated for 30 mins measured after 75 min...More data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion pro...More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged Galphai2 ...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion pro...More data for this Ligand-Target Pair
Affinity DataEC50: 8.70nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoA ...More data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Agonist activity at human Dopamine D2S receptor expressed in HEK293T cell membranes coexpressing GalphaoA incubated for 30 mins measured after 75 min...More data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET a...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Inhibition of human thymidylate synthase at 40 uM concentration of 5,10-CH2-H4PteGlu5More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
Affinity DataEC50: 740nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 r...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Medical University Of Warsaw
Curated by ChEMBL
Medical University Of Warsaw
Curated by ChEMBL
Affinity DataEC50: 24nMAssay Description:Agonistic activity at human 5-HT1A receptor measured after 60 mins by Ultra Lance cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Inverse agonist activity at dopamine D2 receptor (unknown origin) assessed as increase in beta-arrestin-2 recruitmentMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Inverse agonist activity at dopamine D2 receptor (unknown origin) assessed as inhibition of forskolin-mediated cAMP accumulation after 20 mins by rad...More data for this Ligand-Target Pair