BDBM50131270 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide::4'-nitro-3'-trifluoromethylisobutyranilide::CHEMBL806::Eulexin::FLUTAMIDE::Niftolide::alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-m-propionotoluidide::niftolid

SMILES CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI Key InChIKey=MKXKFYHWDHIYRV-UHFFFAOYSA-N

Data  5 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50131270   

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131270(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131270(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of BSEP in human hepatocytes assessed as reduction in biliary excretion of [3H]-taurocholate in cell lysates after 15 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131270(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50131270(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50131270(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50131270(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50131270(2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed