BDBM50132412 1-[5-tert-Butyl-2-(3-dimethylaminomethyl-phenyl)-2H-pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea::CHEMBL318806

SMILES CN(C)Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C

InChI Key InChIKey=HYIPPTOQMVEENL-UHFFFAOYSA-N

Data  1 Kd  1 Koff  1 Kon

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132412   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50132412(1-[5-tert-Butyl-2-(3-dimethylaminomethyl-phenyl)-2...)
Show SMILES CN(C)Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C33H42N6O3/c1-33(2,3)30-22-31(39(36-30)25-10-8-9-24(21-25)23-37(4)5)35-32(40)34-28-13-14-29(27-12-7-6-11-26(27)28)42-20-17-38-15-18-41-19-16-38/h6-14,21-22H,15-20,23H2,1-5H3,(H2,34,35,40)
Affinity DataKon:  0.0000260M-1s-1Assay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50132412(1-[5-tert-Butyl-2-(3-dimethylaminomethyl-phenyl)-2...)
Show SMILES CN(C)Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C33H42N6O3/c1-33(2,3)30-22-31(39(36-30)25-10-8-9-24(21-25)23-37(4)5)35-32(40)34-28-13-14-29(27-12-7-6-11-26(27)28)42-20-17-38-15-18-41-19-16-38/h6-14,21-22H,15-20,23H2,1-5H3,(H2,34,35,40)
Affinity DataKd:  16nMAssay Description:Binding affinity for Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50132412(1-[5-tert-Butyl-2-(3-dimethylaminomethyl-phenyl)-2...)
Show SMILES CN(C)Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C33H42N6O3/c1-33(2,3)30-22-31(39(36-30)25-10-8-9-24(21-25)23-37(4)5)35-32(40)34-28-13-14-29(27-12-7-6-11-26(27)28)42-20-17-38-15-18-41-19-16-38/h6-14,21-22H,15-20,23H2,1-5H3,(H2,34,35,40)
Affinity DataKoff:  1.60E+3s-1Assay Description:Rate of association to Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair