BDBM50140172 CHEBI:3962::CHEMBL140::Curcumin::US20240131036, Example 8::US9409845, Table 1, Compound 21: curcumin
SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
InChI Key InChIKey=VFLDPWHFBUODDF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 136 hits for monomerid = 50140172
Affinity DataIC50: 6.90E+4nMAssay Description:A range of natural products were screened for inhibition of PfGST by GST assay with CDNB as a substrate, using a 96-well SpectraMax 340 microplate sp...More data for this Ligand-Target Pair
Affinity DataIC50: 8.65E+3nMT: 2°CAssay Description:The kinase activity of EGFR was detected according to time-resolved fluorescence detection technology to evaluate automatic phosphorylation levels. T...More data for this Ligand-Target Pair
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of self-mediated amyloid beta (1 to 42) (unknown origin) aggregation after 10 hrs by thioflavin T based fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of recombinant human p300 catalytic domain (1284 to 1673 residues) using histone H3 peptide substrate after 1 hr by liquid scintillation c...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant p300 (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillat...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant CBP (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataIC50: 3.43E+5nMAssay Description:Inhibition of human recombinant BACE1 using M-2420 as substrate preincubated for 1 hr followed by substrate addition incubated for 15 mins by FRET as...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human recombinant GSK3-beta using prephosphorylated polypeptide as substrate incubated for 30 mins by Glo-type luminescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.79E+5nMAssay Description:Binding affinity to recombinant human MD2 (17 to 160 residues) expressed in Escherichia coli BL21(DE3) cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of bovine seminal vesicle COX uing [1-14C]PGH2 as substrate by TLC/liquid scintillation spectrometry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of self-induced amyloid beta 42 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of self-induced amyloid beta 40 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregation incubated for 48 hrs measured after 5 mins by thioflavin-T fluorescenc...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human TAU three-repeat microtubule-binding domain aggregation expressed in Escherichia coli after 16 hrs by thioflavin T fl...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Mouse)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.36E+3nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of recombinant rat N-terminal GST-tagged GSK3beta expressed in Escherichia coli assessed as reduction in tau phosphorylation preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of tau (unknown origin) fibril formation by thioflavin-T fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of tau (unknown origin) fibril formation by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human serum BuChE using butylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 min...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured at 12 se...More data for this Ligand-Target Pair
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measure...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation after 24 hrs by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) self aggregation after 24 hrs by ThT-based fluorometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
Affinity DataEC50: 2.10E+4nMAssay Description:Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of APN (unknown origin)More data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of p300/CBP (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant human PAK1 by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 24 hrs by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) fibrillization (unknown origin) incubated with agitation for 1 min every hr measured over 80 hrs by thioflavin-T...More data for this Ligand-Target Pair
TargetCREB-binding protein/Histone acetyltransferase p300(Human)
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human P300/CBP expressed in Baculovirus expression system using histone as substrate after 10 mins in presence of [3H]-acet...More data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation incubated for 24 hrs under dark condition by thioflavi...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) aggregation after 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of L-type calcium channel in Sprague-Dawley rat aortic rings assessed as reduction in phenylephrine-induced vasoconstriction preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of human amyloid beta (1 to 40) aggregation after 1 hr by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human amyloid beta (1 to 42) aggregation after 46 to 48 hrs by Thioflavin T fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of Abeta42 (unknown origin) aggregation measured after 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human recombinant LSD1 using fluorogenic ADHP as substrate preincubated for 30 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 6.39E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human full-length His6-tagged p300 expressed in baculovirus infected Sf21 insect cells using [3H]acetylCoA as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair