BDBM50142481 7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid::8-aza-11-deoxyprostaglandin E1::CHEMBL42027

SMILES CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O

InChI Key InChIKey=XOPMUDZOEKPBQZ-UHFFFAOYSA-N

Data  16 KI  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50142481   

TargetProstaglandin E2 receptor EP2 subtype(Human)
Cayman Chemical

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Cayman Chemical

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Cayman Chemical

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Cayman Chemical

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataEC50:  0.0650nMAssay Description:Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Cayman Chemical

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Cayman Chemical

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
Cayman Chemical

Curated by ChEMBL
LigandPNGBDBM50142481(8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)...)
Affinity DataKi:  1.46E+3nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed