BDBM50152595 CHEMBL3780091

SMILES N[C@H]1CC[C@H](CC1)Nc1cc[nH]c(=O)c1-c1nc2ccccc2[nH]1

InChI Key InChIKey=JLWGOAGEDWMEBT-TXEJJXNPSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50152595   

TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  3nMAssay Description:Inhibition of JAK1 in human PBMC cells assessed as inhibition of IL-6-induced MCP1 secretionMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetTyrosine-protein kinase JAK2(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  48nMAssay Description:Inhibition of JAK2 in human CD34+ cells assessed as inhibition of EPO-mediated cell proliferationMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetNUAK family SNF1-like kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetSerine/threonine-protein kinase BRSK1(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  2nMAssay Description:Inhibition of BRSK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTyrosine-protein kinase JAK3(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  2.5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  5nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  5.5nMAssay Description:Inhibition of AMPKa1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPlatelet-derived growth factor receptor alpha(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  9nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  0.100nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  1.5nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSerine/threonine-protein kinase SIK2(Human)
Merck

Curated by ChEMBL

LigandBDBM50152595(CHEMBL3780091)Copy SMILESCopy InChI

Affinity DataIC50:  4nMAssay Description:Inhibition of SNF1LK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI