BDBM50160870 CHEMBL3787344::WO2022090481, Example nazartinib

SMILES CN(C)C\C=C\C(=O)N1CCCC[C@H](C1)n1c(NC(=O)c2ccnc(C)c2)nc2cccc(Cl)c12

InChI Key InChIKey=IOMMMLWIABWRKL-WUTDNEBXSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50160870   

TargetEpidermal growth factor receptor/Interleukin-3(Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50: >5.00E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  95nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  1.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  4.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  745nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  455nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  5.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  7.30nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [L858R,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  1.99E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  759nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed