BDBM50160870 CHEMBL3787344::WO2022090481, Example nazartinib
SMILES CN(C)C\C=C\C(=O)N1CCCC[C@H](C1)n1c(NC(=O)c2ccnc(C)c2)nc2cccc(Cl)c12
InChI Key InChIKey=IOMMMLWIABWRKL-WUTDNEBXSA-N
Data 18 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50160870
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 161nMAssay Description:Inhibition of wild type EGFR phosphorylation in human HaCaT cells incubated for 3 hrs by ELISA methodMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in human NCI-H1975 cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of EGFR L858R mutant in human H3255 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR Del ex19 mutant in human HCC827 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor/Interleukin-3(Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: >5.00E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 1.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 4.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 745nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 455nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 5.10nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 7.30nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,C797S](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 1.99E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 759nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair