BDBM50163858 CHEMBL2443188::carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 7

SMILES c1cnc(nc1)SCC(=O)c2ccc(c(c2)Cl)S(=O)(=O)N

InChI Key InChIKey=ZQEDEEFNLDNUEW-UHFFFAOYSA-N

Data  36 Kd  18 Koff  12 Kon

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 66 hits for monomerid = 50163858   

TargetCarbonic anhydrase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  11nMAssay Description:Binding affinity to human recombinant CA2 expressed in Escherichia coli after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.260M-1s-1Assay Description:Binding affinity to human CA9 catalytic domain expressed in mammalian expression system assessed as dissociation rate constant at pH 7 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  0.110nMAssay Description:Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  190nMpH: 8.0Assay Description:Binding affinity to human recombinant CA12 catalytic domain assessed as dissociation constant calculated from saturation signal at pH 8 by surface pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  120nMpH: 8.0Assay Description:Binding affinity to human recombinant CA12 catalytic domain assessed as dissociation constant calculated from kinetic parameters at pH 8 by surface p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.200M-1s-1pH: 8.0Assay Description:Binding affinity to human recombinant CA12 catalytic domain assessed as dissociation rate constant at pH 8 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  110nMAssay Description:Binding affinity to human recombinant CA9 catalytic domain by fluorescence-based thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.0440M-1s-1Assay Description:Binding affinity to human recombinant CA7 assessed as dissociation rate constant after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human recombinant CA2 expressed in Escherichia coli by fluorescence-based thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to CA7 (unknown origin) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  150nMAssay Description:Binding affinity to human recombinant CA9 catalytic domain after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.260M-1s-1Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as dissociation rate constant after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  2nMAssay Description:Binding affinity to human recombinant CA7 by fluorescence-based thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.00420M-1s-1Assay Description:Binding affinity to human recombinant CA2 expressed in Escherichia coli assessed as dissociation rate constant after 30 secs by surface plasmon reson...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human recombinant CA1 expressed in Escherichia coli by fluorescence-based thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  27nMAssay Description:Binding affinity to human recombinant CA1 expressed in Escherichia coli after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.180M-1s-1pH: 8.0Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as dissociation rate constant at pH 8 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  260nMpH: 7.0Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as dissociation constant calculated from saturation signal at pH 7 by surface pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  0.890nMAssay Description:Binding affinity to human CA9 catalytic domain expressed in mammalian expression system assessed as intrinsic thermodynamic equilibrium constant at p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Horse)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  0.760nMAssay Description:Binding affinity to CA1 (unknown origin) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.00420M-1s-1Assay Description:Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Rhesus macaque)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.00840M-1s-1Assay Description:Binding affinity to CA1 (unknown origin) assessed as dissociation rate constant at pH 7 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.320M-1s-1Assay Description:Binding affinity to CA12 (unknown origin) assessed as dissociation rate constant at pH 7 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 13(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  0.170nMAssay Description:Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to CA12 (unknown origin) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 13(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  1.00E-8M-1s-1Assay Description:Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as dissociation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.00460M-1s-1Assay Description:Binding affinity to CA7 (unknown origin) assessed as dissociation rate constant at pH 7 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  17nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  833nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  11nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  5nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 6(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  7.20E+5s-1Assay Description:Binding affinity to human recombinant CA13 assessed as association rate constant after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  330nMAssay Description:Binding affinity to human recombinant CA12 catalytic domain by fluorescence-based thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  200nMAssay Description:Binding affinity to human recombinant CA12 catalytic domain after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKon:  0.320M-1s-1Assay Description:Binding affinity to human recombinant CA12 catalytic domain assessed as dissociation rate constant after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  190nMpH: 8.0Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as dissociation constant calculated from saturation signal at pH 8 by surface pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  100nMpH: 8.0Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as dissociation constant calculated from kinetic parameters at pH 8 by surface pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  1.80E+6s-1pH: 7.0Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as association rate constant at pH 7 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  3.60E+5s-1pH: 6.0Assay Description:Binding affinity to human recombinant CA12 catalytic domain assessed as association rate constant at pH 6 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  4.40E+5s-1pH: 6.0Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as association rate constant at pH 6 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKd:  12nMAssay Description:Binding affinity to human recombinant CA7 after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  1.60E+6s-1Assay Description:Binding affinity to human recombinant CA12 catalytic domain assessed as association rate constant after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  1.80E+6s-1Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as association rate constant after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  3.70E+6s-1Assay Description:Binding affinity to human recombinant CA7 assessed as association rate constant after 30 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  3.90E+5s-1Assay Description:Binding affinity to human recombinant CA2 expressed in Escherichia coli assessed as association rate constant after 30 secs by surface plasmon resona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  3.10E+5s-1Assay Description:Binding affinity to human recombinant CA1 expressed in Escherichia coli assessed as association rate constant after 30 secs by surface plasmon resona...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  1.80E+6s-1pH: 8.0Assay Description:Binding affinity to human recombinant CA12 catalytic domain assessed as association rate constant at pH 8 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 9(Human)
Vilnius University

Curated by ChEMBL
LigandPNGBDBM50163858(carbonic anhydrase (CA) inhibitors, benzenesulphon...)
Affinity DataKoff:  1.70E+6s-1pH: 8.0Assay Description:Binding affinity to human recombinant CA9 catalytic domain assessed as association rate constant at pH 8 by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2017
Entry Details Article
PubMed
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