BDBM50165325 2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclopenta[a]naphthalene-1,4-dione::CHEMBL192554

SMILES COc1ccc(cc1)-c1nn2n(c3ccccc3[nH]c2=O)c1=O

InChI Key InChIKey=PKJGSRHYDOGGLB-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50165325   

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50165325(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Affinity DataKi:  3.76nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha1-beta2-gamma2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50165325(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Affinity DataKi:  14.3nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha2-beta2-gamma2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50165325(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Affinity DataKi:  17.2nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha5-beta3-gamma2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165325(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Affinity DataKi:  49.8nMAssay Description:Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165325(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Affinity DataKi:  1.07E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165325(2-(4-Methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclope...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed