BDBM50170191 CHEMBL182150::N-((cis)-4-(4-(dimethylamino)quinazolin-2-ylamino)cyclohexyl)-3,4-difluorobenzamide::N-[4-(4-Dimethylamino-quinazolin-2-ylamino)-cyclohexyl]-3,4-difluoro-benzamide

SMILES CN(C)c1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)c2ccc(F)c(F)c2)nc2ccccc12

InChI Key InChIKey=FAIMGWSOSCFGRU-IYBDPMFKSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50170191   

TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]rauwolsine from human 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  104nMAssay Description:Displacement of [3H]MK-912 from human adrenergic alpha2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  300nMAssay Description:Displacement of [3H]prazosin from human adrenergic alpha1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  16.9nMAssay Description:Inhibition of human 5HT1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity against alpha-2A adrenergic receptor by using [3H]MK-912 as radioligand expressed in COS-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  9.66nMAssay Description:Displacement of [125I]LSD from human 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed