BDBM50171860 ((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester::CHEMBL363424

SMILES CCOP(=O)(N1Cc2ccccc2C[C@@H]1C(=O)NO)c1ccc(OC)cc1

InChI Key InChIKey=RBLCSCFFNCADJO-UHFFFAOYSA-N

Data  18 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50171860   

TargetInterstitial collagenase(Human)
Organon K.K.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171860BDBM50171860(((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin...)
Affinity DataKi:  4.60nMAssay Description:Inhibitory constant against recombinant human Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Organon K.K.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171860BDBM50171860(((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin...)
Affinity DataKi:  5.10nMAssay Description:Inhibitory constant against recombinant human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Organon K.K.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171860BDBM50171860(((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin...)
Affinity DataKi:  5.20nMAssay Description:Inhibitory constant against recombinant human stromelysin-1 (Matrix metalloprotease-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Organon K.K.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171860BDBM50171860(((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin...)
Affinity DataKi: >650nMAssay Description:Inhibitory constant against recombinant human stromelysin-1 (Matrix metalloprotease-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Organon K.K.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171860BDBM50171860(((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin...)
Affinity DataKi: >800nMAssay Description:Inhibitory constant against recombinant human gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Organon K.K.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50171860BDBM50171860(((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin...)
Affinity DataKi: >850nMAssay Description:Inhibitory constant against recombinant human Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed