BDBM50172430 (E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide::CHEMBL195351

SMILES Cc1cc(nc2ccc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)cc12)N1CCNCC1

InChI Key InChIKey=FXDDFPUEYPXKQX-RUDMXATFSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50172430   

TargetMelanin-concentrating hormone receptor 2(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172430((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Affinity DataIC50: >10nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH2R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172430((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Affinity DataIC50:  88nMAssay Description:Inhibitory concentration against 10 nM MCH-induced IP3 accumulation in CHO-K1 cells expressing human MCH1R after incubation with [3H]-myo-inositolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172430((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Affinity DataIC50:  4nMAssay Description:Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172430((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Affinity DataIC50:  65nMAssay Description:Displacement of 150p M [125I]-MCH from human MCH1R expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
7Tm Pharma

Curated by ChEMBL
LigandPNGBDBM50172430((E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration against human 5-hydroxytryptamine 2C receptor expressed in CHO-K1 cells using [3H]-mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed