BDBM50184410 CHEBI:71013::E-2007::E2007::ER-155055-90::Fycompa::Inhibitor 1 of SARS-CoV-2 Mpro::Perampanel::Perampanel, 1

SMILES O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N

InChI Key InChIKey=PRMWGUBFXWROHD-UHFFFAOYSA-N

Data  7 IC50

PDB links: 6 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50184410   

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM50184410(CHEBI:71013 | E-2007 | E2007 | ER-155055-90 | Fyco...)
Affinity DataIC50:  1.75E+5nMAssay Description:Purified protein is diluted in reaction buffer to 100 nM in an opaque 96-well plate. The protein is incubated with or without compound in DMSO at dif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM50184410(CHEBI:71013 | E-2007 | E2007 | ER-155055-90 | Fyco...)
Affinity DataIC50:  1.75E+5nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-CoV-2Mpro, which was expressed and purified as previously described.8,12 For the...More data for this Ligand-Target Pair
In DepthDetails Article