BDBM50188048 (+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine::(-)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine::1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine::CHEMBL214335

SMILES COc1ccccc1CC(N1CCNCC1)c1ccccc1

InChI Key InChIKey=PFTJCYRHNKTTTO-UHFFFAOYSA-N

Data  10 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50188048   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  840nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  4.95E+3nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi:  4.95E+3nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  4.10E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  3.90E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  3.90E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  18nMAssay Description:Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  1.94E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of DA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50188048((+)-1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazin...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed