BDBM50192768 CHEMBL3900166

SMILES C[C@H]1COC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc1c(C)c3)c2)C1(CCC1)C(O)=O

InChI Key InChIKey=PROYMPSAMYSXNO-WENCNXQZSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50192768   

TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192768(CHEMBL3900166)
Affinity DataKi:  0.140nMAssay Description:Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degCMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192768(CHEMBL3900166)
Affinity DataKi:  725nMAssay Description:Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192768(CHEMBL3900166)
Affinity DataKi:  850nMAssay Description:Inhibition of factor 10a (unknown origin) at 25 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192768(CHEMBL3900166)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of human kallikrein1 at 37 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50192768(CHEMBL3900166)
Affinity DataKi: >1.33E+4nMAssay Description:Inhibition of thrombin (unknown origin) at 25 degC by chromogenic substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed