BDBM50194069 2-(6-chloropyridin-3-yl)-6-aza-bicyclo[2.2.1]heptane::6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]heptane::CHEMBL185667

SMILES Clc1ccc(cn1)C1CC2CNC1C2

InChI Key InChIKey=ISACHQOCISQFPP-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50194069   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50194069(6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.771nMAssay Description:Displacement of [3H]epibatidine from human recombinant alpha4beta2 nAChR in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50194069(6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  6.60nMAssay Description:Inhibition of [3H]cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article

LigandPNGBDBM50194069(6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]hept...)
Affinity DataKi: >38nMAssay Description:Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article

LigandPNGBDBM50194069(6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of [3H]-BTX binding to Nicotinic acetylcholine receptor alpha-7 of rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2010
Entry Details Article

LigandPNGBDBM50194069(6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [125I-alpha]-Bungarotoxin from alpha-7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50194069(6-(6-Chloro-pyridin-3-yl)-2-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [125I-alpha]-Bungarotoxin from alpha-7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed