BDBM50197883 CHEBI:78538::FX-1006::Tafamidis::US10377729, Compound Tafamidis::Vyndaqel

SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N

Data  9 IC50  14 Kd

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50197883   

TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of urea-induced Transthyretin denaturation in human plasma preincubated for 1 hr followed by urea addition by Western blot analysisMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  274nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding si...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.10E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.09E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  278nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as equilibrium dissociation constant of second site by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  370nMAssay Description:Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.10E+3nMAssay Description:In vitro evaluation of inhibitory activity against WT-TTR amyloid fibril formation of AT09 and reference compounds. Reference compounds (thyroxine, t...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  4.40nMAssay Description:Binding affinity to transthyretin (unknown origin) by ITC methodMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  2.80E+3nMAssay Description:Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  1.05E+3nMAssay Description:Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (1...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  3nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as Kd1 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  278nMAssay Description:Binding affinity to wild type TTR (unknown origin) assessed as Kd2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  2.60E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  200nMAssay Description:Binding affinity to TTR V30M mutant (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  410nMAssay Description:Binding affinity to human plasma TTR tetramer assessed as displacement of diclofenac-coupled FITC by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  9.90nMAssay Description:Binding affinity to first binding site of wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  260nMAssay Description:Binding affinity to second binding site of wild type TTR (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...More data for this Ligand-Target Pair