BDBM50199952 CHEMBL219044::methyl 3-(((7R,8R,9alphaR)-8-(3-hydroxyphenyl)-7,8-dimethylhexahydro-1H-pyrido[1,2-R]pyrazin-2(6H)-yl)methyl)benzoate

SMILES COC(=O)c1cccc(CN2CCN3C[C@H](C)[C@@](C)(C[C@@H]3C2)c2cccc(O)c2)c1

InChI Key InChIKey=WIDFGVZFEPVCRU-QRJOEMBSSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50199952   

TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50199952(CHEMBL219044 | methyl 3-(((7R,8R,9alphaR)-8-(3-hyd...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50199952(CHEMBL219044 | methyl 3-(((7R,8R,9alphaR)-8-(3-hyd...)
Affinity DataKi:  140nMAssay Description:Antagonist activity assessed as inhibition of U50488-stimulated [35S]GTP-gamma-S binding to human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50199952(CHEMBL219044 | methyl 3-(((7R,8R,9alphaR)-8-(3-hyd...)
Affinity DataIC50:  6.90nMAssay Description:Antagonist activity assessed as inhibition of loperamide-stimulated [35S]GTPgammaS binding to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed