BDBM50200182 (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol::(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol::(1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol::(5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol::1,25-DHCC::1alpha,25(OH)2D3::1alpha,25-dihydroxycholecalciferol::1alpha,25-dihydroxyvitamin D3::CALCITRIOL::CHEMBL846
SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
InChI Key InChIKey=GMRQFYUYWCNGIN-NKMMMXOESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 89 hits for monomerid = 50200182
Affinity DataKi: 0.0250nMAssay Description:Displacement from vitamin D receptor in chick intestine : 50% displacementMore data for this Ligand-Target Pair
Affinity DataKi: 0.0400nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from full-length recombinant rat VDR by scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 0.0500nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]-1alpha25-(OH)2D3 from full length recombinant rat vitamin D receptor by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of radiolabeled 1alpha,25-(OH)2D3 from rat recombinant full length VDRMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of radiolabelled 1alpha, 25-(OH)2D3 from recombinant rat VDRMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription...More data for this Ligand-Target Pair
Affinity DataEC50: 7.70nMAssay Description:Agonist activity at human VDRMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0260nMAssay Description:Transactivation of VDR-mediated osteocalcin promoter in human HOS/SF cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Transactivation of GAL4-fused VDR ligand binding domain expressed in human HeLa cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [3H]-1-alpha,25-dihydroxyvitamin D3 from N-terminal GST-tagged human recombinant VDR LBD expressed in Escherichia coli Rosetta2 (DE3)...More data for this Ligand-Target Pair
Affinity DataEC50: 7.70nMAssay Description:Inhibition of human VDR-cofactor interaction by EnBio receptor cofactor assay systemMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H]1,25-dihydroxyvitamin D3 from human VDR by HAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Displacement of 1alpha, 25-(OH)[3H]D3 from human VDR expressed in COS1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Displacement of [3H]-1alpha,25-dihydroxyvitamin D3 from recombinant human VDR LBD expressed in Escherichia coli BL21 (DE3) pLysS after 16 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 322nMAssay Description:Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 515nMAssay Description:Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Displacement of [3H]-1,25(OH)2D3 from recombinant human VDR ligand binding domainMore data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at VDR in human HEK293 cells assessed as transcriptional activity after 16 to 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at VDR (unknown origin) expressed in HEK293 cells cotransfected with RXRalpha assessed as RXRalpha recruitment by two-hybrid assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Agonist activity at VDR (unknown origin) expressed in HEK293 cells cotransfected with NCoR assessed as decrease in NCoR recruitment by two-hybrid ass...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Activity at VDR in rat ROS 17/2.8 cells assessed as transcriptional activation of 24-hydroxylase gene promoter after 16 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Activation of VDR in human THP1 cells assessed as increase in 25-hydroxyvitamin D-24-hydroxylase mRNA expression by RT-PCRMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Activation of VDR in human THP1 cells assessed as increase in cathelicidin antimicrobial peptide mRNA expression by RT-PCRMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at VDR expressed in human HuH7 cells after 24 hrs by pDR3-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription...More data for this Ligand-Target Pair
Affinity DataEC50: 3.90nMAssay Description:Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: 223nMAssay Description:Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0500nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from bovine thymus vitamin D receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as induction of 24-hydroxylase reporter gene transcription by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0100nMAssay Description:Activity at human VDR expressed in human HOS cells transfected with pGL3-hOc, pCDNA-hVDR and phRL-TK assessed as assessed as transcriptional activati...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity at rat VDR in ROS 17/2.8 cells transfected with Cyp24a1 reporter plasmid assessed as increase in Cyp24a1 transcription after 16 hrs ...More data for this Ligand-Target Pair
Affinity DataKd: 0.0650nMAssay Description:Binding affinity to VDR receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Transactivation of full length human VDR expressed in human HeLa cells assessed as increase in CYP24 transcription after 18 hrs by luciferase reporte...More data for this Ligand-Target Pair
Affinity DataIC50: 1.24nMAssay Description:Binding affinity to VDR assessed as inhibition of fluorescent ligand by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.28nMAssay Description:Agonist activity at VDR in human MCF7 cells assessed as transcription of CYP24A1 gene after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Activity at VDR in rat osteosarcoma cells assessed as 24-hydroxylase transcription by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0500nMAssay Description:Displacement of 1-alpha,25-dihydroxyvitamin from rat recombinant VDRMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:Displacement of [3H]1,25-(OH)2D3 from vitamin D receptor in bovine thymusMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Induction of transactivation of human VDR responsive gene in COS7 cells by rat osteopontin luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at VDR ligand binding domain (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Binding affinity to VDR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-ga...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at CMX-GAL4 tagged human VDR expressed in HEK293 cells assessed as increase in transcriptional activity by luciferase reporter gene ...More data for this Ligand-Target Pair