BDBM50203419 CHEMBL3915997

SMILES C[C@H](NC(=O)C(F)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)c1ccccc1

InChI Key InChIKey=UITKQZZSZUEHEA-NYHFZMIOSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50203419   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50:  0.130nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to ERalpha (unknown origin) by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50:  2.70nMAssay Description:Binding affinity to GR (unknown origin) by FP assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to ERbeta (unknown origin) by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50:  0.130nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50:  910nMAssay Description:Binding affinity to PR (unknown origin) by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50: >5.00E+3nMAssay Description:Binding affinity to AR (unknown origin) by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50:  0.5nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203419(CHEMBL3915997)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of 3H-aldosterone from MR (unknown origin) ligand binding domain by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed