BDBM50223368 3beta-hydroxyandrost-5-en-17-one::CHEMBL90593::DHEAS::Dehydroepiandrosterone (1)::Prasterone

SMILES C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O

InChI Key InChIKey=FMGSKLZLMKYGDP-USOAJAOKSA-N

Data  6 KI  7 IC50  1 Kd  2 EC50

PDB links: 8 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50223368   

TargetSolute carrier organic anion transporter family member(Danio rerio (Zebrafish))
Rudjer Boskovic Institute

LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataKi:  680nMAssay Description:In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Trypanosoma brucei)
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of Trypanosoma brucei G6PDH using NADP as substrate by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Trypanosoma brucei)
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of Trypanosoma brucei G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Homo sapiens (Human))
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibition of human G6PDH using NADP as substrate by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Homo sapiens (Human))
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataKi:  8.90E+3nMAssay Description:Inhibition of human G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticosteroid-binding globulin(Homo sapiens)
Nippon Zoki Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity to human CBG receptor (corticosteroid-binding globulins)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Homo sapiens (Human))
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University Of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataIC50:  7.79E+4nMAssay Description:Inhibition of beta-glucuronidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Homo sapiens (Human))
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of G6PD (unknown origin) assessed as reduction in 6-phospho-D-glucono-1,5-lactone and NADPH production using glucose-6-phosphate and NADP+...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Homo sapiens (Human))
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataIC50:  2.49E+4nMAssay Description:Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Basel

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Centre National de la Recherche Scientifique/INSERM/ULP

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataEC50:  3.33E+3nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSex hormone-binding globulin(Homo sapiens (Human))
University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataKd:  14nMAssay Description:Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-6-phosphate 1-dehydrogenase(Homo sapiens (Human))
Universidade De SãO Paulo

Curated by ChEMBL
LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of G6PD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-glucuronidase(Escherichia coli (Enterobacteria))
University Of Karachi

LigandPNGBDBM50223368(3beta-hydroxyandrost-5-en-17-one | CHEMBL90593 | D...)
Affinity DataIC50:  7.79E+4nMpH: 7.0 T: 2°CAssay Description:β-Glucuronidase inhibitory activity was evaluated by a biochemical assay, based on the measurement of the absorbance of p-nitrophenol at 405 nm,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed