BDBM50224395 2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5'':4',5']thieno[3',2':5,6]pyrido[3,4-b][1,4]oxazin-8(9H)-one::CHEMBL235975

SMILES Cc1ccc(cc1)-n1cnc2c(sc3ncc4OCCNc4c23)c1=O

InChI Key InChIKey=ATPSAOLGMWJQNL-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50224395   

TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224395(2,3-dihydro-9-(4-methylphenyl)-1H-pyrimido[4'',5''...)
Affinity DataIC50:  702nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed