BDBM50232589 5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine::CHEMBL255019

SMILES Nc1nc(N)c2c(COc3cccc(Cl)c3)cccc2n1

InChI Key InChIKey=KIRSNYVHLHEFJS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232589   

TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of DHFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed