BDBM50236025 CHEMBL2016761::US11149049, No. C2::US20240140975, Compound A109

SMILES Nc1ncnn2c(ccc12)[C@@]1(O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C#N

InChI Key InChIKey=DFVPCNAMNAPBCX-LTGWCKQJSA-N

Data  7 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50236025   

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2 | US20240140975...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human mitochondrial RNA polymerase after 30 mins in presence of [33P]GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2 | US20240140975...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human DNA polymerase alpha preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2 | US20240140975...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human DNA polymerase beta preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed