BDBM50236697 5-L-isoleucineangiotensin II::5-isoleucine-angiotensin II::Angiotensin II::Asp-Arg-Val-Tyr-Ile-His-Pro-Phe::CHEMBL408403::Ile(5)-angiotensin II::L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine::N-(1-(N-(N-(N-(N-(N(2)-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine::US9624243, Angiotensin II::angiotensin II (human)::angiotensin II (mouse)::human angiotensin II::isoleucine(5)-angiotensin II

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI Key InChIKey=CZGUSIXMZVURDU-UHFFFAOYSA-N

Data  6 KI  4 IC50  2 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50236697   

TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-Angiotensin 2 from human placental AT1 receptor expressed in African green monkey COS7 cell membranes after 90 mins by gamma cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataEC50:  0.520nMAssay Description:Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataIC50: 0.724nMAssay Description:Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed