BDBM50236697 5-L-isoleucineangiotensin II::5-isoleucine-angiotensin II::Angiotensin II::Asp-Arg-Val-Tyr-Ile-His-Pro-Phe::CHEMBL408403::Ile(5)-angiotensin II::L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine::N-(1-(N-(N-(N-(N-(N(2)-L-alpha-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine::US9624243, Angiotensin II::angiotensin II (human)::angiotensin II (mouse)::human angiotensin II::isoleucine(5)-angiotensin II

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI Key InChIKey=CZGUSIXMZVURDU-UHFFFAOYSA-N

Data  6 KI  4 IC50  2 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50236697   

TargetType-2 angiotensin II receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataIC50: 0.724nMAssay Description:Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetType-2 angiotensin II receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataIC50: 1.80nMAssay Description: 120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. The binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50236697BDBM50236697(L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-iso...)
Affinity DataIC50: 2nMAssay Description:Angiotensin II receptor antagonist activity was determined by 50% inhibition of specific binding of [3H]angiotensin II (2 nM) to rat adrenal cortical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2018
Entry Details