BDBM50241453 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one::CHEMBL260553::gamma-mangostin

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc2oc3cc(-[#8])c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c3c(=O)c2c1-[#8]

InChI Key InChIKey=VEZXFTKZUMARDU-UHFFFAOYSA-N

Data  4 KI  11 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50241453   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50241453(1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant C-terminal 6xHis-tagged MTH1 (3 to 156 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50241453(1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair